The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice

• Main Authors: Sei Higuchi (Author), Keiichi Irie (Author), Shohei Mishima (Author), Maiko Araki (Author), Makiko Ohji (Author), Atsunori Shirakawa (Author), Yoshiharu Akitake (Author), Kiyoshi Matsuyama (Author), Kenji Mishima (Author), Kenichi Mishima (Author), Katsunori Iwasaki (Author), Michihiro Fujiwara (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endocannabinoids have been shown to activate reward-related feeding and to promote astrocytic differentiation. We investigated whether high-fat diet (HFD) intake produced a preference for HFD via an endocannabinoid-dependent mechanism. In the conditioned place preference test, the 2-week HFD-intake...