Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

• Main Authors: Feng-Sheng Wang (Author), Chung-Wen Kuo (Author), Jih-Yang Ko (Author), Yu-Shan Chen (Author), Shao-Yu Wang (Author), Huei-Jing Ke (Author), Pei-Chen Kuo (Author), Chin-Huei Lee (Author), Jian-Ching Wu (Author), Wen-Bin Lu (Author), Ming-Hong Tai (Author), Holger Jahr (Author), Wei-Shiung Lian (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle homeostasis. Little is known about the effect of...