Carborane-Based ABCG2-Inhibitors Sensitize ABC-(Over)Expressing Cancer Cell Lines for Doxorubicin and Cisplatin

• Main Authors: Svetlana Paskas (Author), Philipp Stockmann (Author), Sanja Mijatović (Author), Lydia Kuhnert (Author), Walther Honscha (Author), Evamarie Hey-Hawkins (Author), Danijela Maksimović-Ivanić (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The ABCG2 transporter protein, as part of several known mechanisms involved in multidrug resistance, has the ability to transport a broad spectrum of substrates out of the cell and is, therefore, considered as a potential target to improve cancer therapies or as an approach to combat drug resistance...