Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats
Purpose: This animal experiment investigated how sesame seed (Sesamum indicum; SSI) extract affects bone metabolism in ovariectomized (Ovx) rats. Materials and methods: Female Wistar rats (12 weeks old) were randomly assigned to the Baseline control (BC), Sham, Ovx, and Ovx + SSI groups (n = 6-10)....
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
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IMR Press,
2020-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Purpose: This animal experiment investigated how sesame seed (Sesamum indicum; SSI) extract affects bone metabolism in ovariectomized (Ovx) rats. Materials and methods: Female Wistar rats (12 weeks old) were randomly assigned to the Baseline control (BC), Sham, Ovx, and Ovx + SSI groups (n = 6-10). Animals in the BC group were sacrificed immediately. Rats in the other groups underwent sham surgery (Sham) or bilateral ovariectomy (Ovx and Ovx + SSI). Rats in the Ovx + SSI group were given custom diets, and BMD and bone histomorphometry were evaluated 13 weeks post-surgery. Results: The femur BMD in the Ovx + SSI group was lower than in the Ovx group, as were the measurements for bone formation rate and mineralizing surface. Conclusion: Administration of a methanol extract of sesame seeds decreased femur BMD in Ovx rats. |
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| Item Description: | 0390-6663 10.31083/j.ceog.2020.04.5144 |