Urinary Iron Excretion is Associated with Urinary Full-Length Megalin and Renal Oxidative Stress in Chronic Kidney Disease

• Main Authors: Shinya Nakatani (Author), Ayumi Nakatani (Author), Eiji Ishimura (Author), Norikazu Toi (Author), Akihiro Tsuda (Author), Katsuhito Mori (Author), Masanori Emoto (Author), Yoshiaki Hirayama (Author), Akihiko Saito (Author), Masaaki Inaba (Author)
• Format: Book
• Published: Karger Publishers, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Megalin mediates the uptake of glomerular-filtered iron in the proximal tubules. Urinary full length megalin (C-megalin) excretion has been found to be increased in association with megalin-mediated metabolic load to the endo-lysosomal system in proximal tubular epithelial cells (PT...