Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

• Main Authors: Mette Trauelsen (Author), Elisabeth Rexen Ulven (Author), Siv A. Hjorth (Author), Matjaz Brvar (Author), Claudia Monaco (Author), Thomas M. Frimurer (Author), Thue W. Schwartz (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools. Methods and results: Here we first determined that the cis conformation of the succinate backb...