Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Objective: Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools. Methods and results: Here we first determined that the cis conformation of the succinate backb...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2017-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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