Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage

• Main Authors: Rebecca M. Green (Author), Weiguo Feng (Author), Tzulip Phang (Author), Jennifer L. Fish (Author), Hong Li (Author), Richard A. Spritz (Author), Ralph S. Marcucio (Author), Joan Hooper (Author), Heather Jamniczky (Author), Benedikt Hallgrímsson (Author), Trevor Williams (Author)
• Format: Book
• Published: The Company of Biologists, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Failure of facial prominence fusion causes cleft lip and palate (CL/P), a common human birth defect. Several potential mechanisms can be envisioned that would result in CL/P, including failure of prominence growth and/or alignment as well as a failure of fusion of the juxtaposed epithelial seams. He...