Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man

Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man

AimsSmall conductance Ca2+-activated K+ channels (SK channels, KCa2) are a new target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor of KCa2 channels that is currently in clinical development for treatment of AF. The aim of this study is to present the electrophysio...

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Main Authors: Bo Hjorth Bentzen (Author), Sofia Hammami Bomholtz (Author), Rafel Simó-Vicens (Author), Lasse Folkersen (Author), Lea Abildgaard (Author), Tobias Speerschneider (Author), Kalai Mangai Muthukumarasamy (Author), Nils Edvardsson (Author), Ulrik S. Sørensen (Author), Morten Grunnet (Author), Jonas Goldin Diness (Author)
Format: Book
Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
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