Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid

• Main Authors: Verena Hugenberg (Author), Malte Behrends (Author), Stefan Wagner (Author), Sven Hermann (Author), Michael Schäfers (Author), Hartmuth C. Kolb (Author), Katrin Szardenings (Author), Joseph C. Walsh (Author), Luis F. Gomez (Author), Klaus Kopka (Author), Günter Haufe (Author)
• Format: Book
• Published: SpringerOpen, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background To study MMP activity in vivo in disease, several radiolabeled MMP inhibitors functioning as radiotracers have been evaluated by means of SPECT and PET. Unfortunately, most of them suffer from metabolic instability, mainly hepatobiliary clearance and insufficient target binding....