Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid

• Автори: Verena Hugenberg (Автор), Malte Behrends (Автор), Stefan Wagner (Автор), Sven Hermann (Автор), Michael Schäfers (Автор), Hartmuth C. Kolb (Автор), Katrin Szardenings (Автор), Joseph C. Walsh (Автор), Luis F. Gomez (Автор), Klaus Kopka (Автор), Günter Haufe (Автор)
• Формат: Книга
• Опубліковано: SpringerOpen, 2018-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background To study MMP activity in vivo in disease, several radiolabeled MMP inhibitors functioning as radiotracers have been evaluated by means of SPECT and PET. Unfortunately, most of them suffer from metabolic instability, mainly hepatobiliary clearance and insufficient target binding....