LPM3770277, a Potent Novel CDK4/6 Degrader, Exerts Antitumor Effect Against Triple-Negative Breast Cancer

• Main Authors: Jiahao Qiu (Author), Xinfa Bai (Author), Wenjing Zhang (Author), Mingxu Ma (Author), Wenyan Wang (Author), Ye Liang (Author), Hongbo Wang (Author), Jingwei Tian (Author), Pengfei Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triple negative breast cancer (TNBC) is a subtype of breast cancer with significant malignancy and poor prognosis but effective treatments are limited. Given the critical role of CDK4/6 in cell cycle and the apparent success of CDK4/6 inhibitors against certain cancer, this study attempted to utiliz...