Development of a Gene and Nucleic Acid Delivery System for Skeletal Muscle Administration via Limb Perfusion Using Nanobubbles and Ultrasound

• Main Authors: Shohko Sekine (Author), Sayaka Mayama (Author), Nobuaki Nishijima (Author), Takuo Kojima (Author), Yoko Endo-Takahashi (Author), Yuko Ishii (Author), Hitomi Shiono (Author), Saki Akiyama (Author), Akane Sakurai (Author), Sanae Sashida (Author), Nobuhito Hamano (Author), Rui Tada (Author), Ryo Suzuki (Author), Kazuo Maruyama (Author), Yoichi Negishi (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Strategies for gene and nucleic acid delivery to skeletal muscles have been extensively explored to treat Duchenne muscular dystrophy (DMD) and other neuromuscular diseases. Of these, effective intravascular delivery of naked plasmid DNA (pDNA) and nucleic acids into muscles is an attractive approac...