Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy

• Glavni autori: Natalia Siwecka (Autor), Kamil Saramowicz (Autor), Grzegorz Galita (Autor), Wioletta Rozpędek-Kamińska (Autor), Ireneusz Majsterek (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2023-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

α-synuclein (α-syn) is an intrinsically disordered protein abundant in the central nervous system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release in the presynaptic terminals. Pathologies related to misfolding and aggregation of α-syn are referred to as α-syn...