Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner.

• Main Authors: Cheng Huang (Author), Olga A Kolokoltsova (Author), Nadezdha E Yun (Author), Alexey V Seregin (Author), Allison L Poussard (Author), Aida G Walker (Author), Allan R Brasier (Author), Yingxin Zhao (Author), Bing Tian (Author), Juan Carlos de la Torre (Author), Slobodan Paessler (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Junín virus (JUNV), an arenavirus, is the causative agent of Argentine hemorrhagic fever, an infectious human disease with 15-30% case fatality. The pathogenesis of AHF is still not well understood. Elevated levels of interferon and cytokines are reported in AHF patients, which might be correlated...