Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner.

• Autori principali: Cheng Huang (Autore), Olga A Kolokoltsova (Autore), Nadezdha E Yun (Autore), Alexey V Seregin (Autore), Allison L Poussard (Autore), Aida G Walker (Autore), Allan R Brasier (Autore), Yingxin Zhao (Autore), Bing Tian (Autore), Juan Carlos de la Torre (Autore), Slobodan Paessler (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Junín virus (JUNV), an arenavirus, is the causative agent of Argentine hemorrhagic fever, an infectious human disease with 15-30% case fatality. The pathogenesis of AHF is still not well understood. Elevated levels of interferon and cytokines are reported in AHF patients, which might be correlated...