Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws.

• Hlavní autoři: Lorenzo Giacani (Autor), Lawrence R Bernstein (Autor), Austin M Haynes (Autor), B Charmie Godornes (Autor), Giulia Ciccarese (Autor), Francesco Drago (Autor), Aurora Parodi (Autor), Sefora Valdevit (Autor), Luca Anselmi (Autor), Carlo Francesco Tomasini (Autor), Arthur M Baca (Autor)
• Médium: Kniha
• Vydáno: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

<h4>Background</h4>Gallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, particularly DNA synthesis (due to inhibition of...