Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws.

• Main Authors: Lorenzo Giacani (Author), Lawrence R Bernstein (Author), Austin M Haynes (Author), B Charmie Godornes (Author), Giulia Ciccarese (Author), Francesco Drago (Author), Aurora Parodi (Author), Sefora Valdevit (Author), Luca Anselmi (Author), Carlo Francesco Tomasini (Author), Arthur M Baca (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Gallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, particularly DNA synthesis (due to inhibition of...