Development of a PHBV nanoparticle as a peptide vehicle for NOD1 activation

• Main Authors: Mauricio Cabaña-Brunod (Author), Pablo A. Herrera (Author), Valeria Márquez-Miranda (Author), Felipe M. Llancalahuen (Author), Yorley Duarte (Author), Danilo González-Nilo (Author), Juan A. Fuentes (Author), Cristián Vilos (Author), Luis Velásquez (Author), Carolina Otero (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NOD1 is an intracellular receptor that, when activated, induces gene expression of pro-inflammatory factors promoting macrophages and neutrophils recruitment at the infection site. However, iE-DAP, the dipeptide agonist that promotes this receptor's activation, cannot permeate cell membranes. T...