An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

• Main Authors: Samantha E Wilner (Author), Brian Wengerter (Author), Keith Maier (Author), Maria de Lourdes Borba Magalhães (Author), David Soriano Del Amo (Author), Supriya Pai (Author), Felipe Opazo (Author), Silvio O Rizzoli (Author), Amy Yan (Author), Matthew Levy (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The transferrin receptor, CD71, is an attractive target for drug development because of its high expression on a number of cancer cell lines and the blood brain barrier. To generate serum-stabilized aptamers that recognize the human transferrin receptor, we have modified the traditional aptamer sele...