Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease

• Main Authors: Qi Zhu (Author), Juxian Song (Author), Jia-Yue Chen (Author), Zhenwei Yuan (Author), Liangfeng Liu (Author), Li-Ming Xie (Author), Qiwen Liao (Author), Richard D. Ye (Author), Xiu Chen (Author), Yepiao Yan (Author), Jieqiong Tan (Author), Chris Soon Heng Tan (Author), Min Li (Author), Jia-Hong Lu (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is the most common neurodegenerative movement disease. It is featured by abnormal alpha-synuclein (α-syn) aggregation in dopaminergic neurons in the substantia nigra. Macroautophagy (autophagy) is an evolutionarily conserved cellular process for degradation of cellular...