Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death

• Hoofdauteurs: Zheng-Wei Lee (Auteur), Xin-Yi Teo (Auteur), Zhi J. Song (Auteur), Dawn S. Nin (Auteur), Wisna Novera (Auteur), Bok A. Choo (Auteur), Brian W. Dymock (Auteur), Philip K. Moore (Auteur), Ruby Y.-J. Huang (Auteur), Lih-Wen Deng (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Slow and continuous release of H2S by GYY4137 has previously been demonstrated to kill cancer cells by increasing glycolysis and impairing anion exchanger and sodium/proton exchanger activity. This action is specific for cancer cells. The resulting lactate overproduction and defective pH homeostasis...