Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death

• Main Authors: Zheng-Wei Lee (Author), Xin-Yi Teo (Author), Zhi J. Song (Author), Dawn S. Nin (Author), Wisna Novera (Author), Bok A. Choo (Author), Brian W. Dymock (Author), Philip K. Moore (Author), Ruby Y.-J. Huang (Author), Lih-Wen Deng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Slow and continuous release of H2S by GYY4137 has previously been demonstrated to kill cancer cells by increasing glycolysis and impairing anion exchanger and sodium/proton exchanger activity. This action is specific for cancer cells. The resulting lactate overproduction and defective pH homeostasis...