Pharmacokinetic Evaluation of Metabolic Drug Interactions between Repaglinide and Celecoxib by a Bioanalytical HPLC Method for Their Simultaneous Determination with Fluorescence Detection

• Main Authors: Dong-Gyun Han (Author), Jinsook Kwak (Author), Seong-Wook Seo (Author), Ji-Min Kim (Author), Jin-Wook Yoo (Author), Yunjin Jung (Author), Yun-Hee Lee (Author), Min-Soo Kim (Author), Young-Suk Jung (Author), Hwayoung Yun (Author), In-Soo Yoon (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since diabetes mellitus and osteoarthritis are highly prevalent diseases, combinations of antidiabetic agents like repaglinide (REP) and non-steroidal anti-inflammatory drugs (NSAID) like celecoxib (CEL) could be commonly used in clinical practice. In this study, a simple and sensitive bioanalytical...