Challenges in conducting fractional polynomial and standard parametric network meta-analyses of immune checkpoint inhibitors for first-line advanced renal cell carcinoma

• Main Authors: Svenja Petersohn (Author), Bradley McGregor (Author), Sven L Klijn (Author), Jessica R May (Author), Flavia Ejzykowicz (Author), Murat Kurt (Author), Matthew Dyer (Author), Bill Malcolm (Author), Sebastien Branchoux (Author), Katharina Nickel (Author), Saby George (Author), Sonja Kroep (Author)
• Format: Book
• Published: Becaris Publishing Limited, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Network meta-analyses (NMAs) increasingly feature time-varying hazards to account for nonproportional hazards between different drug classes. This paper outlines an algorithm for selecting clinically plausible fractional polynomial NMA models. Methods: The NMA of four immune checkpoint inhibito...