Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

• Main Authors: Alan Umfress (Author), Sarbjit Singh (Author), Kevin J. Ryan (Author), Ayanabha Chakraborti (Author), Florian Plattner (Author), Yogesh Sonawane (Author), Jayapal Reddy Mallareddy (Author), Edward P. Acosta (Author), Amarnath Natarajan (Author), James A. Bibb (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer's disease, and Parkinson's disease. While constitutive...