Nanotoxicologic Effects of PLGA Nanoparticles Formulated with a Cell-Penetrating Peptide: Searching for a Safe pDNA Delivery System for the Lungs

• Main Authors: Larissa Gomes dos Reis (Author), Wing-Hin Lee (Author), Maree Svolos (Author), Lyn Margaret Moir (Author), Rima Jaber (Author), Norbert Windhab (Author), Paul Michael Young (Author), Daniela Traini (Author)
• Format: Book
• Published: MDPI AG, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of cell-penetrating peptides (CPPs) in combination with nanoparticles (NPs) shows great potential for intracellular delivery of DNA. Currently, its application is limited due to the potential toxicity and unknown long-term side effects. In this study NPs prepared using a biodegradable polyme...