Systemic Design and Evaluation of Ticagrelor-Loaded Nanostructured Lipid Carriers for Enhancing Bioavailability and Antiplatelet Activity

• Main Authors: Gi-Ho Son (Author), Young-Guk Na (Author), Hyun Wook Huh (Author), Miao Wang (Author), Min-Ki Kim (Author), Min-Gu Han (Author), Jin-Ju Byeon (Author), Hong-Ki Lee (Author), Cheong-Weon Cho (Author)
• Format: Book
• Published: MDPI AG, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ticagrelor (TGL), a P2Y₁₂ receptor antagonist, is classified as biopharmaceutics classification system (BCS) class IV drug due to its poor solubility and permeability, resulting in low oral bioavailability. Nanostructured lipid carriers (NLC) are an efficient delivery system f...