Effect of Protein Binding on Exposure of Unbound and Total Mycophenolic Acid: A Population Pharmacokinetic Analysis in Chinese Adult Kidney Transplant Recipients

• Autori principali: Changcheng Sheng (Autore), Qun Zhao (Autore), Wanjie Niu (Autore), Xiaoyan Qiu (Autore), Ming Zhang (Autore), Zheng Jiao (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

ObjectivesThe population pharmacokinetic (popPK) characteristics of total mycophenolic acid (tMPA) have been investigated in various ethnic populations. However, investigations of popPK of unbound MPA (uMPA) are few. Thus, a popPK analysis was performed to: (1) characterize the PK of uMPA and tMPA a...