Saponin Micelles Lead to High Mucosal Permeation and In Vivo Efficacy of Solubilized Budesonide

• Main Authors: Sabine Nakowitsch (Author), Christiane Koller (Author), Jan-Marcus Seifert (Author), Marielle König-Schuster (Author), Nicole Unger-Manhart (Author), Cornelia Siegl (Author), Norman Kirchoff (Author), Elisabeth Foglar (Author), Christine Graf (Author), Martina Morokutti-Kurz (Author), Marianne Neurath (Author), Svenja Sladek (Author), Christian Knecht (Author), Wolfgang Sipos (Author), Eva Prieschl-Grassauer (Author), Andreas Grassauer (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to fast nasal mucociliary clearance, only the dissolved drug content can effectively permeate the mucosa and be pharmaceutically active after intranasal application of suspensions. Therefore, the aim of this study was to increase the budesonide concentration in solution of a nasal spray formulat...