Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

• Main Authors: Olga A. Patutina (Author), Svetlana K. Miroshnichenko (Author), Nadezhda L. Mironova (Author), Aleksandra V. Sen'kova (Author), Elena V. Bichenkova (Author), David J. Clarke (Author), Valentin V. Vlassov (Author), Marina A. Zenkova (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. miRNases comprise a peptide [(LeuArg)2Gly]2 capable...