Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

• Главные авторы: Olga A. Patutina (Автор), Svetlana K. Miroshnichenko (Автор), Nadezhda L. Mironova (Автор), Aleksandra V. Sen'kova (Автор), Elena V. Bichenkova (Автор), David J. Clarke (Автор), Valentin V. Vlassov (Автор), Marina A. Zenkova (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. miRNases comprise a peptide [(LeuArg)2Gly]2 capable...