Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. miRNases comprise a peptide [(LeuArg)2Gly]2 capable...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2019-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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