Synthesis and evaluation of some new 1,2,4-triazolo(4,3-a)quinoxalin-4-5H-one derivatives as AMPA receptor antagonists

• Main Authors: Ashraf Bayoumi (Author), Adel Ghiaty (Author), Ahmed El-Morsy (Author), Hamada Abul-Khair (Author), Memy H. Hassan (Author), Salwa Elmeligie (Author)
• Format: Book
• Published: Faculty of Pharmacy, Cairo University, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study involves the synthesis and anticonvulsant evaluation of 1-ethyl-3-hydrazinylquinoxalin-2-1H-one (8), and many other newly synthesized compounds (9-14). The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1H NMR and Mass). Docking studies w...