CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

• Main Authors: Han Zeng (Author), Hong Qin (Author), Meng Liao (Author), Enze Zheng (Author), Xiaoqing Luo (Author), Anhua Xiao (Author), Yiyu Li (Author), Lin Chen (Author), Li Wei (Author), Lei Zhao (Author), Xiong Z. Ruan (Author), Ping Yang (Author), Yaxi Chen (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Enhanced de novo lipogenesis (DNL) in hepatocytes is a major contributor to nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase (FAT/CD36) is involved in the pathogenesis of NAFLD through facilitating free fatty acids uptake. Here, we explored the effects of CD36 on DNL and e...