CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

• Главные авторы: Han Zeng (Автор), Hong Qin (Автор), Meng Liao (Автор), Enze Zheng (Автор), Xiaoqing Luo (Автор), Anhua Xiao (Автор), Yiyu Li (Автор), Lin Chen (Автор), Li Wei (Автор), Lei Zhao (Автор), Xiong Z. Ruan (Автор), Ping Yang (Автор), Yaxi Chen (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2022-03-01T00:00:00Z.
• Предметы: article
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Objective: Enhanced de novo lipogenesis (DNL) in hepatocytes is a major contributor to nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase (FAT/CD36) is involved in the pathogenesis of NAFLD through facilitating free fatty acids uptake. Here, we explored the effects of CD36 on DNL and e...