Efficient Delivery of Hydrophilic Small Molecules to Retinal Cell Lines Using Gel Core-Containing Solid Lipid Nanoparticles

• Main Authors: Li Huang (Author), Erico Himawan (Author), Soumaya Belhadj (Author), Raúl Oswaldo Pérez García (Author), François Paquet Durand (Author), Nicolaas Schipper (Author), Matej Buzgo (Author), Aiva Simaite (Author), Valeria Marigo (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we developed a novel solid lipid nanoparticle (SLN) formulation for drug delivery of small hydrophilic cargos to the retina. The new formulation, based on a gel core and composite shell, allowed up to two-fold increase in the encapsulation efficiency. The type of hydrophobic polyester...