Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease

• Main Authors: Judith A. Voynow (Author), Shuo Zheng (Author), Apparao B. Kummarapurugu (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Neutrophil elastase (NE) is a major protease in the airways of patients with cystic fibrosis (CF) that activates airway inflammation by several mechanisms. NE stimulates epithelial toll like receptors (TLR) resulting in cytokine upregulation and release, upregulates MUC5AC, a major airway mucin, deg...