Regulatory Role of the MicroRNA-29b-IL-6 Signaling in the Formation of Vascular Mimicry

• Main Authors: Jian-Hong Fang (Author), Zhi-Yuan Zheng (Author), Jin-Yu Liu (Author), Chen Xie (Author), Zi-Jun Zhang (Author), Shi-Mei Zhuang (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular mimicry (VM) is a critical complement for microcirculation and is implicated in tumor progression. We showed that IL-6 derived from tumor cells and stroma cells promoted tumor cells to form a VM structure, whereas blocking the IL-6 signaling by RNA interference, IL-6-neutralizing antibody,...