Profiling donepezil template into multipotent hybrids with antioxidant properties

• Main Authors: Eva Mezeiova (Author), Katarina Spilovska (Author), Eugenie Nepovimova (Author), Lukas Gorecki (Author), Ondrej Soukup (Author), Rafael Dolezal (Author), David Malinak (Author), Jana Janockova (Author), Daniel Jun (Author), Kamil Kuca (Author), Jan Korabecny (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist memantine. However, their therapeutic effect is...