Lipophosphoglycans from Leishmania amazonensis Strains Display Immunomodulatory Properties via TLR4 and Do Not Affect Sand Fly Infection.

• Main Authors: Paula M Nogueira (Author), Rafael R Assis (Author), Ana C Torrecilhas (Author), Elvira M Saraiva (Author), Natália L Pessoa (Author), Marco A Campos (Author), Eric F Marialva (Author), Cláudia M Ríos-Velasquez (Author), Felipe A Pessoa (Author), Nágila F Secundino (Author), Jerônimo N Rugani (Author), Elsa Nieves (Author), Salvatore J Turco (Author), Maria N Melo (Author), Rodrigo P Soares (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species...