NPD-0414-2 and NPD-0414-24, Two Chemical Entities Designed as Aryl Hydrocarbon Receptor (AhR) Ligands, Inhibit Gut Inflammatory Signals

• Main Authors: Irene Marafini (Author), Davide Di Fusco (Author), Vincenzo Dinallo (Author), Eleonora Franzè (Author), Carmine Stolfi (Author), Giuseppe Sica (Author), Giovanni Monteleone (Author), Ivan Monteleone (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Defects in counterregulatory mechanisms contribute to amplify the detrimental inflammatory response leading to the pathologic process occurring in the gut of patients with Crohn's disease (CD) and ulcerative colitis (UC), the major inflammatory bowel diseases (IBDs), in human beings. One such m...