In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changes.

• Main Authors: Julius Mulindwa (Author), Geofrey Ssentamu (Author), Enock Matovu (Author), Kevin Kamanyi Marucha (Author), Francisco Aresta-Branco (Author), Claudia Helbig (Author), Christine Clayton (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Most researchers who study unicellular eukaryotes work with an extremely limited number of laboratory-adapted isolates that were obtained from the field decades ago, but the effects of passage in laboratory rodents, and adaptation to in vitro culture, have been little studied. For example, the vast...