A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model

• Main Authors: Misato Ito (Author), Shunji Yamazaki (Author), Kaoru Yamagami (Author), Masako Kuno (Author), Yoshiaki Morita (Author), Kenji Okuma (Author), Koji Nakamura (Author), Noboru Chida (Author), Masamichi Inami (Author), Takayuki Inoue (Author), Shohei Shirakami (Author), Yasuyuki Higashi (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Janus kinase (JAK) family of tyrosine kinases is associated with various cytokine receptors. JAK1 and JAK3 play particularly important roles in the immune response, and their inhibition is expected to provide targeted immune modulation. Several oral JAK inhibitors have recently been developed fo...