Paclitaxel-Loaded Silk Fibroin Nanoparticles: Method Validation by UHPLC-MS/MS to Assess an Exogenous Approach to Load Cytotoxic Drugs

• Hauptverfasser: Sara Perteghella (Verfasst von), Cristina Sottani (Verfasst von), Valentina Coccè (Verfasst von), Sara Negri (Verfasst von), Loredana Cavicchini (Verfasst von), Giulio Alessandri (Verfasst von), Danilo Cottica (Verfasst von), Maria Luisa Torre (Verfasst von), Elena Grignani (Verfasst von), Augusto Pessina (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2019-06-01T00:00:00Z.
• Schlagworte: article
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The aim of this work was to load an anticancer drug, paclitaxel (PTX), on Silk Fibroin Nanoparticles (SFNs) by using an exogenous approach. SFNs were produced, freeze-dried and then loaded with PTX. An exogenous method allowed us to reduce both drug loss and environmental impact. In order to quantif...