Truncated C-terminus of fibrillin-1 induces Marfanoid-progeroid-lipodystrophy (MPL) syndrome in rabbit

• Главные авторы: Mao Chen (Автор), Bing Yao (Автор), Qiangbing Yang (Автор), Jichao Deng (Автор), Yuning Song (Автор), Tingting Sui (Автор), Lina Zhou (Автор), HaoBing Yao (Автор), Yuanyuan Xu (Автор), Hongsheng Ouyang (Автор), Daxin Pang (Автор), Zhanjun Li (Автор), Liangxue Lai (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2018-04-01T00:00:00Z.
• Предметы: article
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Various clinical differences have been observed between patients with the FBN1 gene mutation and those with the classical Marfan phenotype. Although FBN1 knockout (KO) or dominant-negative mutant mice are widely used as an animal model for Marfan syndrome (MFS), these mice cannot recapitulate the ge...