Ciclopirox inhibits SARS-CoV-2 replication by promoting the degradation of the nucleocapsid protein

• Main Authors: Xiafei Wei (Author), Yuzheng Zhou (Author), Xiaotong Shen (Author), Lujie Fan (Author), Donglan Liu (Author), Xiang Gao (Author), Jian Zhou (Author), Yezi Wu (Author), Yunfei Li (Author), Wei Feng (Author), Zheng Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The nucleocapsid protein (NP) plays a crucial role in SARS-CoV-2 replication and is the most abundant structural protein with a long half-life. Despite its vital role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assembly and host inflammatory response, it remains an unexplored tar...