Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload

• Main Authors: Nan Zhang (Author), Hai-Han Liao (Author), Hong Feng (Author), Shan-Qi Mou (Author), Wen-Jing Li (Author), Xiahenazi Aiyasiding (Author), Zheng Lin (Author), Wen Ding (Author), Zi-Ying Zhou (Author), Han Yan (Author), Si Chen (Author), Qi-Zhu Tang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Sestrin2 (Sesn2) has been demonstrated to be a cysteine sulfinyl reductase and protects cells from multiple stress insults, including hypoxia, endoplasmic reticulum stress, and oxidative stress. However, the roles and mechanisms of Sesn2 in pressure overload-induced mouse cardiac hypertr...