Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach

• Päätekijät: Nikola Stefanović (Tekijä), Radmila Veličković-Radovanović (Tekijä), Katarina Danković (Tekijä), Ivan Pavlović (Tekijä), Aleksandra Catić-Đorđević (Tekijä), Jelena Bašić (Tekijä), Milena Despotović (Tekijä), Tatjana Jevtović-Stoimenov (Tekijä), Branka Mitić (Tekijä), Tatjana Cvetković (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2021-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

<b>Background</b>: Tacrolimus (Tac) is characterized by large between- and within-patient (IPV) variability in pharmacokinetics and exposure. <b>Aim</b>: This study aimed to assess and validate the effect of Tac IPV and trough concentration-to-dose ratio (C<sub>0</su...