Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach

• Main Authors: Nikola Stefanović (Author), Radmila Veličković-Radovanović (Author), Katarina Danković (Author), Ivan Pavlović (Author), Aleksandra Catić-Đorđević (Author), Jelena Bašić (Author), Milena Despotović (Author), Tatjana Jevtović-Stoimenov (Author), Branka Mitić (Author), Tatjana Cvetković (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background</b>: Tacrolimus (Tac) is characterized by large between- and within-patient (IPV) variability in pharmacokinetics and exposure. <b>Aim</b>: This study aimed to assess and validate the effect of Tac IPV and trough concentration-to-dose ratio (C<sub>0</su...