Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

• Main Authors: Sylwia Wasiak (Author), Dean Gilham (Author), Emily Daze (Author), Laura M. Tsujikawa (Author), Christopher Halliday (Author), Stephanie C. Stotz (Author), Brooke D. Rakai (Author), Li Fu (Author), Ravi Jahagirdar (Author), Michael Sweeney (Author), Jan O. Johansson (Author), Norman C. W. Wong (Author), Ewelina Kulikowski (Author)
• Format: Book
• Published: Hindawi-Wiley, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates with the abundance of acute phase response (APR) proteins in the liver and plasma. Bromodomain and extraterminal (BET) proteins are epigenetic readers that regulate inflammatory gene transcription. We show that...