Single synchronous delivery of FK506-loaded polymeric microspheres with pancreatic islets for the successful treatment of streptozocin-induced diabetes in mice

• Main Authors: Shiva Pathak (Author), Shobha Regmi (Author), Biki Gupta (Author), Bijay K. Poudel (Author), Tung Thanh Pham (Author), Chul Soon Yong (Author), Jong Oh Kim (Author), Jae-Ryong Kim (Author), Min Hui Park (Author), Young Kyung Bae (Author), Simmyung Yook (Author), Cheol-Hee Ahn (Author), Jee-Heon Jeong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune rejection after transplantation is common, which leads to prompt failure of the graft. Therefore, to prolong the survival time of the graft, immunosuppressive therapy is the norm. Here, we report a robust immune protection protocol using FK506-loaded microspheres (FK506M) in injectable hydrog...