Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

• Main Authors: Memoona Rashid (Author), Muhammad Sarfraz (Author), Mosab Arafat (Author), Amjad Hussain (Author), Nasir Abbas (Author), Muhammad Waqas Sadiq (Author), Muhammad Fawad Rasool (Author), Nadeem Irfan Bukhari (Author)
• Format: Book
• Published: BMC, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric doses and ignores the age-related physiological differences. Methods A...