Chain-Branched Polyhydroxylated Octahydro-<i>1H</i>-Indoles as Potential Leads against Lysosomal Storage Diseases
Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1<i>H</i>-indole-4,5,6-triols are reported. This study shows the transformation of <span style="font-variant: small-caps;">d</span>-glucose into polyhydroxylated 1-(2-n...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2019-03-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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| Summary: | Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1<i>H</i>-indole-4,5,6-triols are reported. This study shows the transformation of <span style="font-variant: small-caps;">d</span>-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the azacyclopentane ring. Results of inhibitory potency assays and docking calculations show that at least one of them could be a lead for optimization in the search for compounds that behave like folding chaperones in lysosomal storage diseases. |
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| Item Description: | 1424-8247 10.3390/ph12020047 |