Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series

• Main Authors: Jarinda A. Poppe (Author), Willem van Weteringen (Author), Lotte L. G. Sebek (Author), Catherijne A. J. Knibbe (Author), Irwin K. M. Reiss (Author), Sinno H. P. Simons (Author), Robert B. Flint (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionCurrent drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly alter pharmacokinetics and pharmacodynamics. Evaluation of drug therapy in these patients is very difficult because objective pharma...