Design, Synthesis, and Antitumor Evaluation of an Opioid Growth Factor Bioconjugate Targeting Pancreatic Ductal Adenocarcinoma

• Main Authors: Justyna Budka (Author), Dawid Debowski (Author), Shaoshan Mai (Author), Magdalena Narajczyk (Author), Stanislaw Hac (Author), Krzysztof Rolka (Author), Eirinaios I. Vrettos (Author), Andreas G. Tzakos (Author), Iwona Inkielewicz-Stepniak (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) presents a formidable challenge with high lethality and limited effective drug treatments. Its heightened metastatic potential further complicates the prognosis. Owing to the significant toxicity of current chemotherapeutics, compounds like [Met<sup>5<...